delivery, magnetic hyperthermia, MPI, and MRI owing to their biocompatibility,

biodegradability, high stability, and most importantly ease of maneuvering them

using an external magnetic field. Moreover, the physiological and chemical

properties of MNPs can be tailored according to the requirement by altering the

method of synthesis and surface coatings. MNP-based drug delivery allows the

MNPs to accumulate at specific locations such as tumor cells and enables demolition

by releasing drug at the targeted cells without affecting the healthy cells. This

MNP-based targeted therapy helps to mitigate the side effects and drug resistance

as well as assist in the invasive medical interventions. MNP-based imaging is one of

the most adaptable imaging techniques as it provides high-resolution images and

allows diagnosing and grading diseases such as cancer at its earlier stage. In spite of

several advantages in nanomedicine, MNPs are also associated with some

limitations such as weak magnetization of biocompatible MNPs and requirement

of the large-size MNPs to be applied for MH applications that causes difficulty in

their excretion from the body. Thus, the future challenges will certainly involve the

development of superparamagnetic nanoparticles of the optimized size that allows

for stronger magnetic responsivity while maintaining their biocompatibility and

enabling enhanced renal clearance.

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